Single Molecules
Single Molecules |
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| 1 | ADHESION FORCES BETWEEN INDIVIDUAL LIGAND-RECEPTOR PAIRS EL. Florin, (florin@chaos.utexas.edu )VT. Moy, (vmoy@newssun.med.miami.edu )HE. Gaub, (gaub@lmu.de ) Science (1994-04-15) 264-5157 p.415 Science publications Publisher : AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA. ISSN : 0036-8075 Abstract : The adhesion force between the tip of an atomic force microscope cantilever derivatized with avidin and agarose beads functionalized with biotin, desthiobiotin, or iminobiotin was measured. Under conditions that allowed only a limited number of molecular pairs to interact, the force required to separate tip and bead was found to be quantized in integer multiples of 160 +/- 20 piconewtons for biotin and 85 +/- 15 piconewtons for iminobiotin. The measured force quanta are interpreted as the unbinding forces of individual molecular pairs. Corresponding Author : Affiliation(s) : (0) TECH UNIV MUNICH,DEPT PHYS,D-85748 GARCHING,GERMANY.; Key words : MICROSCOPE; CELLS; MOLECULES; CRYSTALS Type : Article, English. 1994-04-15 Time cited 702; Journal impact factor for year 1994 equals 22.067 [0] ASHKIN A, 1987, NATURE, V330, P769 [1] BINNIG G, 1986, PHYS REV LETT, V56, P930 [2] DARST SA, 1991, BIOPHYS J, V59, P387 [3] DRAKE B, 1989, SCIENCE, V243, P1586 [4] EGGER M, 1992, BIOCHIM BIOPHYS ACTA, V1104, P45 [5] EVANS E, IN PRESS [6] EVANS E, 1991, BIOPHYS J, V59, P838 [7] FLORIN EL, 1994, REV SCI INSTRUM, V65, P639 [8] FRAUENFELDER H, 1988, ANNU REV BIOPHYS BIO, V17, P451 [9] GREEN NM, 1975, ADV PROTEIN CHEM, V29, P85 [10] HELM CA, 1991, P NATL ACAD SCI USA, V88, P8169 [11] ISRAELACHVILI JN, 1992, INTERMOLECULAR SURFA [12] KARRASCH S, 1993, BIOPHYS J, V65, P2437 [13] KUO SC, 1993, SCIENCE, V260, P232 [14] LEE GU, 1994, LANGMUIR, V10, P354 [15] LIVNAH O, 1993, P NATL ACAD SCI USA, V90, P5076 [16] MARCHAND P, 1983, REV SCI INSTRUM, V54, P1034 [17] MOY VT, UNPUB [18] PETHICA JB, 1987, PHYS SCRIPTA TA, V19, P61 [19] PIERCE M, UNPUB [20] RADMACHER M, 1992, SCIENCE, V257, P1900 [21] SMITH SB, 1992, SCIENCE, V258, P1122 [22] SVOBODA K, 1993, NATURE, V365, P721 [23] WANG N, 1993, SCIENCE, V260, P1124 |
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