To achieve strong forces, the magnets need to be placed very close to the magnetic beads. PicoTwist has designed a special sample holder where this distance can be as small as 100 μm. The sample holder is made of a micro-channel cut in thin, double-sided tape sandwiched between a glass cover slip at the bottom and a thin mylar sheet at the top. This mylar sheet extends futher away from the cover slip and is used to maintain and to translate it above the microscope objective.

The small micro-channel is connected to small tubings allowing one to change buffers and infuse enzyme and other reagents into the micro-channel.

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