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| 1 | Geometric control of cell life and death CS. Chen, M. Mrksich, S. Huang, GM. Whitesides, DE. Ingber, (donald.ingber@childrens.harvard.edu ) Science (1997-05-30) 276-5317 p.1425 Science publications Publisher : AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA. ISSN : 0036-8075 Abstract : Human and bovine capillary endothelial cells were switched from growth to apoptosis by using micropatterned substrates that contained extracellular matrix-coated adhesive islands of decreasing size to progressively restrict cell extension. Cell spreading also was varied while maintaining the total cell-matrix contact area constant by changing the spacing between multiple focal adhesion-sized islands. Cell shape was found to govern whether individual cells grow or die, regardless of the type of matrix protein or antibody to integrin used to mediate adhesion. Local geometric control of cell growth and viability may therefore represent a fundamental mechanism for developmental regulation within the tissue microenvironment. Corresponding Author : Affiliation(s) : (0) HARVARD UNIV,SCH MED,CHILDRENS HOSP,DEPT SURG,BOSTON,MA 02115.; (1) HARVARD UNIV,SCH MED,CHILDRENS HOSP,DEPT PATHOL,BOSTON,MA 02115.; (2) HARVARD UNIV,DEPT CHEM,CAMBRIDGE,MA 02138.; Key words : SELF-ASSEMBLED MONOLAYERS; FIBROBLAST GROWTH-FACTOR; EXTRACELLULAR-MATRIX; BASEMENT-MEMBRANE; INTEGRIN ALPHA(V)BETA(3); GENE-EXPRESSION; FOCAL ADHESIONS; BLOOD-VESSELS; ANGIOGENESIS; SHAPE Type : Article, English. 1997-05-30 Time cited 772; Journal impact factor for year 1997 equals 24.676 [0] BOUDREAU N, 1995, SCIENCE, V267, P891 [1] BROOKS PC, 1994, CELL, V79, P1157 [2] BROOKS PC, 1994, SCIENCE, V264, P569 [3] BROOKS PC, 1995, J CLIN INVEST, V96, P1815 [4] BURRIDGE K, 1988, ANNU REV CELL BIOL, V4, P487 [5] CLARK EA, 1995, SCIENCE, V268, P233 [6] CLARK ER, 1939, AM J ANAT, V64, P251 [7] CRAIG SW, 1996, CURR OPIN CELL BIOL, V8, P74 [8] DIKE LE, 1996, J CELL SCI 12, V109, P2855 [9] DRAKE CJ, 1995, J CELL SCI 7, V108, P2655 [10] FALCONE DJ, 1993, J BIOL CHEM, V268, P11951 [11] FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182 [12] FOLKMAN J, 1975, BIOCHIM BIOPHYS ACTA, V417, P217 [13] FOLKMAN J, 1978, NATURE, V273, P345 [14] FOLKMAN J, 1988, AM J PATHOL, V130, P393 [15] FOLKMAN J, 1989, NATURE, V339, P58 [16] FRISCH SM, 1996, J CELL BIOL, V134, P793 [17] HANAHAN D, 1996, CELL, V86, P353 [18] HANKS SK, 1992, P NATL ACAD SCI USA, V89, P8487 [19] INGBER D, 1990, NATURE, V348, P555 [20] INGBER DE, 1981, P NATL ACAD SCI-BIOL, V78, P3901 [21] INGBER DE, 1982, TUMOR INVASION METAS, P335 [22] INGBER DE, 1985, AM J PATHOL, V12, P248 [23] INGBER DE, 1985, GENE EXPRESSION NORM, P13 [24] INGBER DE, 1986, ENDOCRINOLOGY, V119, P1768 [25] INGBER DE, 1989, CELL, V58, P308 [26] INGBER DE, 1989, J CELL BIOL, V109, P317 [27] INGBER DE, 1990, P NATL ACAD SCI USA, V87, P3579 [28] INGBER DE, 1993, CELL, V75, P1249 [29] INGBER DE, 1993, J CELL SCI, V104, P613 [30] INGBER DE, 1997, ANN REV PHYS, V59, P75 [31] KUMAR A, 1994, LANGMUIR, V10, P1498 [32] MACPHERSON I, 1964, VIROLOGY, V23, P291 [33] MANIOTIS AJ, 1997, P NATL ACAD SCI USA, V94, P849 [34] MCNAMEE HP, 1993, J CELL BIOL, V121, P673 [35] MEREDITH JE, 1993, MOL BIOL CELL, V4, P953 [36] MIYAMOTO S, 1995, SCIENCE, V267, P883 [37] MRKSICH M, 1995, TRENDS BIOTECHNOL, V13, P228 [38] OWENS LV, 1995, CANCER RES, V55, P2752 [39] PLOPPER GE, 1995, MOL BIOL CELL, V6, P1349 [40] PRIME KL, 1991, SCIENCE, V252, P1164 [41] RE F, 1994, J CELL BIOL, V127, P537 [42] ROSKELLEY CD, 1995, CURR OPIN CELL BIOL, V7, P736 [43] SCHALLER MD, 1992, P NATL ACAD SCI USA, V89, P5192 [44] SCHWARTZ MA, 1991, P NATL ACAD SCI USA, V88, P7849 [45] SCHWARTZ MA, 1995, ANNU REV CELL DEV BI, V11, P549 [46] SINGHVI R, 1994, SCIENCE, V264, P696 [47] SPIVAKKROIZMAN T, 1994, CELL, V79, P1015 [48] STAMENOVIC D, 1996, J THEOR BIOL, V181, P125 [49] STOKER M, 1968, INT J CANCER, V3, P683 [50] STROMBLAD S, 1996, J CLIN INVEST, V98, P426 [51] SYMPSON CJ, 1994, J CELL BIOL, V125, P681 [52] TUCKER RW, 1981, J SUPRAMOL STRUCT CE, V15, P29 [53] WANG N, 1993, SCIENCE, V260, P1124 [54] WANG N, 1994, BIOPHYS J, V66, P2181 [55] WANG N, 1995, BIOCHEM CELL BIOL, V73, P327 [56] WICHA MS, 1980, DEV BIOL, V80, P253 [57] WITTELSBERGER SC, 1981, CELL, V24, P859 [58] ZHANG ZH, 1995, P NATL ACAD SCI USA, V92, P6161 |
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